Depleting the H3K9me3 methyltransferase Suv39h1 in a progeria mouse model reduces H3K9me3 levels, delays senescence in progeroid cells, and extends lifespan, but whether perturbation of Suv39h1 can extend lifespan in healthy mice is not known (Liu et al., 2013). The gene discussed is SUV39H1; the disease is progeroid syndrome.