Baseline IGF-1 (IGF-1/ULN) at the time of diagnosis of acromegaly was 3 ± 1.4 ULN (range 1.4 to 5.6).Of the 75 patients, 63 (84%) had images consistent with macroadenomas, and 10 (13.3%) with microadenomas. The gene discussed is IGF1; the disease is acromegaly.