For patients with diabetes and heart failure, the risk of hypotension due to the association of ACE inhibitors or angiotensin II receptor antagonists with diuretics to treat hypertension becomes even more clinically relevant.(13) This hypotension is a consequence of the sodium depletion produced by the ACE inhibitor that is potentiated by the additive action of the diuretic. The gene discussed is ACE; the disease is hypertensive disorder.