CD4 and cranioectodermal dysplasia: CD4+ T cells specific for gluten are enriched in intestinal tissue and may also be present in gut-associated secondary lymphoid organs, but in blood from HLA-DQ2.5+ CeD patients on GFD memory, CD4+ T cells specific for epitopes in Nexvax2 have a median frequency estimated to be only 4 per million CD4+ T cells (5).