Last, the cytokine profiles of freshly isolated B cells were investigated because gluten- and TG2-specific B cells are implicated in CeD, and B cells and plasma cells are the most abundant cell type presenting the immunodominant gluten peptide DQ2.5-glia-α1a in the inflamed intestinal tissues of CeD patients (23). Here, TGM2 is linked to cranioectodermal dysplasia.