So, based on these findings we could indicated that mushroom glucans could activate NK-TNF family ligands in the presence of target cancer cells that in turn induce IFNγ production that that reflect the positive effects of IFNγ on NK -tumor cell lysis process (Aquino-Lopez et al., 2017), and that this ability is enhanced in the presence of IL-2. This evidence concerns the gene IFNG and neoplasm.