NKG2D is crucial for surveillance toward spontaneous malignancies (Molfetta et al., 2017) and plays an important role in NK cell-mediated recognition and control of different cancer entities including B cell lymphoma, multiple myeloma, osteosarcoma, prostate cancer, cervical cancer, and childhood AML (Garcia-Iglesias et al., 2009; Belting et al., 2015; Fernández et al., 2015; Fionda et al., 2015; Pasero et al., 2015; Schlegel et al., 2015). Here, KLRK1 is linked to osteosarcoma.