In animal models of polymicrobial sepsis, neonates tend to show lower absolute plasma concentrations of TNF-α, IL-1α/β, IL-12, GM-CSF, CCL5 (RANTES), macrophage inflammatory protein (MIP)-1β and IFN-γ as compared to adults, when challenged with an equally-lethal dose of “cecal slurry” (59). Here, TNF is linked to Sepsis.