TNF and Sepsis: Second, other cytokines such as IL-6 and IL-10, the latter being an important soluble mediator for resolution of inflammation (62), seem to be produced by septic neonates in comparable or sometimes higher amounts compared to adult patients (63, 64), and several studies correlated the adverse outcomes of sepsis (i.e., septic shock or non survival) with higher concentrations of IL-10 and higher IL-10/TNF-α ratio, in neonates as well as in adults (33, 65, 66).