SOD2 and Hyperglycemia: Furthermore, differences between adults and neonates exist also for what concerns endothelium metabolism: for example, HUVECs, as compared to human microvascular ECs (HMVEC) derived from adults, express higher levels of hydrogen peroxide and lower amounts of ROS-neutralizing enzymes, such as superoxide dismutase 2 (SOD2) and catalase, in response to hyperglycemia (76): this study suggests a potential epigenetic-mediated difference between neonatal and adult ECs in the capacity to neutralize ROS.