TNF and metabolic dysfunction-associated steatohepatitis: Moreover, a study of NLRP3- and NLRP6-deficient NASH model mice showed that promoting dysbiosis initiated colitis through the secretory C-C motif chemokine ligand 5 (commonly known as CCL5); ultimately, the consequent increased amounts of TLR4 ligand and TLR6 ligand reaching the liver via portal blood and the enhanced hepatic TNF-α production resulted in acceleration of the NASH state (27, 28).