USP14 and melanoma: For example, Usp14 overexpression was observed in lung, breast, pancreatic, gastric, and endometrial cancer (289, 295, 299) and its inhibition via RNA interference or small molecule inhibitors resulted in reduced proliferation invasion and increased apoptosis in lung, breast, pancreatic, prostate, endometrial cancer, and melanoma cells (288, 289, 295, 296).