SP1 and nasopharyngeal carcinoma: Studies have also reported that miR-519d sensitizes NPC cells to radiation by directly targeting the 3′-UTR of PDRG1 (p53 and DNA damage regulated 1) mRNA (70) and thatiR-24 increases radiosensitivity in NPC by targeting both COPS5 and SP1 (specificity protein 1) (15).