A study of NPC tumor specimens found that tumor-suppressing protein PDCD4 suppresses the pPI3K/pAKT/c-JUN signaling pathway, which in turn modulates miR-374a's binding to CCND1, resulting in dysregulation of NPC cell growth, metastasis, and chemoresistance (65). This evidence concerns the gene PDCD4 and nasopharyngeal carcinoma.