A direct target of miR-125b, the tumor necrosis factor alpha-induced protein 3 gene TNFAIP3 (formerly called A20), functions as a tumor suppressor in NPC and mediates miR-125b-promoted NPC tumorigenesis by activating the nuclear factor κB (NF-κB) signaling pathway. Here, NFKB1 is linked to nasopharyngeal carcinoma.