SIRT5 and breast cancer: For example, either the mRNA or protein expression of SIRT5 was found to be increased in non-small cell lung cancer (NSCLC) (12, 13), hepatocellular carcinoma (HCC) (14), colorectal cancer (CRC) (15), Waldenstrom macroglobulinemia (16), and breast cancer (9, 17), compared to the levels in matched normal tissues.