Moreover, in our study, the Nrf2/HO-1 pathway was found to be positively regulated by SIRT5 and overexpression of SIRT5 facilitated Nrf2 nuclear translocation, consistent with a report that the mRNA levels of Nrf2 and its downstream target genes are reduced upon SIRT5 knockdown in NSCLC (13). This evidence concerns the gene NFE2L2 and non-small cell lung carcinoma.