IFFO1 and neoplasm: IFFO1, encoding a primordial component of the cytoskeleton and nuclear envelope, has been detected with specific methylation patterns and expression profiles in the PDX mouse model of lung cancer (Anglim et al., 2008) and ovarian cancer (Houshdaran et al., 2010), but not in other tumor tissues, indicating that the specific expression pattern of this gene may be a potential biomarker for identifying lung cancer and ovarian cancer.