PVT1 and neoplasm: For example, the lncRNA growth arrest-specific transcript 5 (GAS5), which is down-regulated in almost all tumor tissues, can suppress the tumorigenesis of cervical cancer by downregulating miR-196a and miR-205 (Yang et al., 2017), while LncRNA-PVT1, which is up-regulated in non-small cell lung cancer (NSCLC), can improve tumor invasion and metastasis (Yang et al., 2014).