AKT1 and Insulin resistance: Notably, five genes encoding enriched DEPs were related to insulin resistance (SLC27A2 and phosphoenolpyruvate carboxykinase [PCK]1), insulin secretion (phosphoinositide phospholipase C-β2 [PLCB2]), insulin signaling (PCK1), PI3K/Akt signaling (PCK1), AMPK signaling (PCK1), and PPAR signaling (cytochrome P450 family 4 subfamily A member [CYP4A]11, SLC27A2, carnitine palmitoyltransferase [CPT]2, and PCK1).