Although, splenic cMBC and MZB cell percentages were decreased in HBV-LC patients, there was no significant correlation between the percentages of splenic Tfh cells and the percentages of most of B cell subsets including MZBs, aMBCs, cMBCs, naïve B cells, and CXCR5+CD4+ T cells. Here, CXCR5 is linked to laryngotracheoesophageal cleft.