We finally analyzed the correlations between splenic Tfh cell proportion and several clinical markers reflecting disease severity such as Child-Pugh score, ALB, PTA, TBIL, et al. We found that HBV-LC patients with higher Child-Pugh scores displayed more splenic Tfh cell proportion than those with lower scores (Figure 7A), although there were no significant correlations between splenic Tfh cell proportion and the levels of ALB, PTA, and TBIL (Figures 7B–D). This evidence concerns the gene ALB and laryngotracheoesophageal cleft.