We did not observe any other conclusive differences in bacterial or fungal alpha-diversity in a complication occurrence context (bronchiectasis, autoimmunity, splenomegaly, chronic diarrhea, atrophic gastritis, and nodular hyperplasia) (Supplementary Table S8), treatment administration (antibiotic use, substitution therapy type or immunosuppression), or serum IgM levels, however, data analyses in most groups/categories may be burdened by a small number error. The gene discussed is CD40LG; the disease is Splenomegaly.