Gene profiling of NK from the tumor where antigen-specific CTL were present showed a strong expression of effector (Gzma, Gzmb, Prf1, and 4.1BB), tissue–migratory (Gpr33 and Ccr5), and signaling (Ifngr, Klhdc2, Eif3s6, Map3k6, Tnfrsf1b, Icos, Ly49G, and Nmi) transcripts. This evidence concerns the gene TNFRSF1B and neoplasm.