CD4 and tuberculosis: Indeed, the recruitment of a larger number of the TB/HIV patients, as initially planned, was not achieved along the period of the study support, possibly due to the implementation by the Brazilian Ministry of Health of the free early access to antiretrovirals in the recent years, independently of the CD4+ T-cell counts and clinical conditions, and also INH prophylaxis for some HIV-infected patients, restricting our access to participants with CD4+ T-cell counts <200 cells/mm3, a inclusion criteria to the TB/HIV and the HIV patients (86).