BRAF and neoplasm: The paradox of pediatric DTC—with its worse presentation at diagnosis, but good outcome—could therefore be explained by a greater differentiation of the tumor cells and a consequently better response to radiometabolic treatments and TSH suppression therapy (22, 23) and also by a lower frequency of BRAF mutations (24) Regarding the potential effects of continued levothyroxine suppression, TSH contributes to the regulation of thyrocyte differentiation by modulating thyroid gene levels (25).