Our study aimed to characterize pediatric DTC in a large monocentric series of patients, most of them not exposed to radiation, focusing on: (i) clinical features and outcomes; (ii) molecular profile, with particular reference to the study of point mutations of the BRAF, RAS, TERT genes, and RET/PTC translocations; (iii) correlations between clinical and molecular findings; and (iv) comparisons between the clinical and molecular profile of pediatric DTC and that of a large series of adult thyroid carcinoma cases coming from our center. This evidence concerns the gene TERT and thyroid gland carcinoma.