TNF and neoplasm: Besides IFN-γ, we also examined many other immune cytokines involved in the anti-tumor response of CT26, such as IL-12, from Th1 cells (Komai-Koma et al., 2016); IL-6 from antigen-presenting cells (Brahmakshatriya et al., 2017); and TNF-α from macrophages (Tessaro et al., 2017).