CXCR6 and Familial prostate cancer: Wang et al. (2008) have shown that the expression of CXCR6 increases with the grade of prostate cancer. These results were supported by Lu et al. (2008) who observed that metastatic cells from prostate cancer overexpress the CXCR6 receptor. Moreover, CXCL16 have been shown to induce the migration and enhance the proliferation of CXCR6-expressing cancer cells in vitro (Darash-Yahana et al., 2009).