As indicated by the Annexin V-FITC/PI assay, miR-21-miRNase increased necrosis of melanoma B16 cells to a limited extent (up to 7%) similar (up to 6.5%) to the sham peptide-oligonucleotide conjugate, luc-POC (for luc-POC sequence see Supplementary Table 1) with a sequence of a firefly luciferase gene with no complementarity to the mammalian genome. Here, ANXA5 is linked to melanoma.