Even in the cases of neuropathological AD diagnosis (i.e., secured Abeta and Tau pathology in histology), 55% of cases also exhibited a pathology of alpha synuclein (which we would expect in synucleinopathies like Parkinson's disease) and 40% showed transactive response DNA binding protein 43kDa (TDP-43), a protein which we would expect in frontotemporal dementia or amyotrophic lateral sclerosis (Robinson et al., 2018b). This evidence concerns the gene APP and Alzheimer disease.