NBP is protective against cognitive impairment induced by CCH by increasing sonic hedgehog/patched 1 pathway markers and decreasing endoplasmic reticulum stress-related markers (Niu et al., 2018), or activating the AKT/Nrf2 pathway in the hippocampus of rats (Qi et al., 2018). The gene discussed is AKT1; the disease is columnar cell hyperplasia of the breast.