The microtubule-associated protein tau undergoes transitions from soluble monomer to oligomer and subsequently into paired helical filaments that comprise the neurofibrillary tangles (NFTs), a pathological hallmark in Alzheimer’s disease (AD) and other neurodegenerative disorders (Lee et al., 2001; Guo et al., 2017; Polanco et al., 2017). The gene discussed is MAPT; the disease is Alzheimer disease.