The association of EFhd2 and tau in AD, identification of EFhd2 and tau in filamentous structures, their colocalization in the somatodendritic compartment and copurification in the sarkosyl-insoluble fraction indicates that EFhd2 is associated with pathological tau in AD (Vega et al., 2008; Ferrer-Acosta et al., 2013a). The gene discussed is MAPT; the disease is Alzheimer disease.