Further characterization of the EFhd2-tau association demonstrated that EFhd2 colocalized with pathological tau in the somatodendric compartment in AD and this association is increasingly detected as neurodegeneration progresses in JNPL3 mice (Vega et al., 2008; Ferrer-Acosta et al., 2013a). This evidence concerns the gene MAPT and Alzheimer disease.