MAPT and tauopathy: These findings are in accordance with data from the human brain that describe: (1) GVBs in sporadic tauopathy patients as well as in MAPT mutation carriers; (2) GVBs in tauopathies characterized by the predominance of 3R or 4R tau isoforms or both in the aggregates [3, 39, 50, 64, 76].