VPREB3 and immune system disorder: Among the 43 DEPS are 13 immune disease related genes37,38 such as SOCS5 and SOCS6 (suppressors of cytokine signaling, whose role in cancer is still under investigation51), EBF1 (early B-cell Factor 1), CD160, TCL1A (T-cell leukemia/lymphoma 1A), VPREB3 (pre-B lymphocyte 3), KLF10 (Kruppel-like factor 10), NTM (neurotrimin), PLXNA4 (plexin A4), SLC25A21, SYT4 (synaptotagmin 4) and TCERG1 (transcription elongation regulator 1).