Several cancer entities such as oral squamous cell carcinoma (OSCC), non-small cell lung cancer (NSCLC), hepatocellular carcinoma (HCC), esophageal cancer, pancreatic cancer, erythroleukemia, breast cancer, bladder cancer and colorectal cancer displayed an overexpression of the S1P-synthesizing enzyme SPHK1 which is therefore announced as a potential prognostic tumor marker [15, 20–27]. This evidence concerns the gene SPHK1 and hepatocellular carcinoma.