SERPINB2 and cancer: For example, SerpinB2 has been reported (i) to modulate Th1/Th2 immunity20–25, (ii) to inhibit apoptosis in certain settings20,26–28, (iii) to inhibit cancer metastasis and migration18,29–31, (iv) to regulate differentiation and proliferation32–36 and (v) to inhibit IL-1β processing37.