Using control MGH7 cells, a lung squamous cell carcinoma cell line with high levels of NRF229,30 (Fig. 4A), we identified a lentiviral shRNA construct (shRNA2) that was especially effective at reducing protein levels of NRF2 and the NRF2 target gene, NQO1 (Fig. 4A,B). This evidence concerns the gene NQO1 and squamous cell lung carcinoma.