Indeed, we found that although in the TCGA lung adenocarcinoma data, the cumulative alteration frequency of NRF2, KEAP1, and CUL3 is 23% (Supplementary Fig. S1), 58% of patients within our lung adenocarcinoma cohort had high levels of NRF2 protein (Table 1). This evidence concerns the gene CUL3 and lung adenocarcinoma.