We found that immune-modulated ZIKV infection with the anti-IFNAR1 antibody resulted in more robust induction of Tfh (CXCR5highPD-1high) and pre-Tfh (CXCR5mediumPD-1medium) than direct ZIKV infection without antibody treatment or uninfected control. Here, IFNAR1 is linked to Zika virus infectious disease.