After ZIKV infection, IFN-γ receptor-deficient Tfh cells developed normally, with slight reduction of pre-Tfh cells (Fig. 8a), and these cells could produce similar levels of IFN-γ, compared with CD45.1+ wild-type Tfh cells in the same chimeras (Fig. 8b), consistent with that in Ifngr1−/− mice (Supplementary Fig. 10a). This evidence concerns the gene IFNG and Zika virus infectious disease.