IFNG and Zika virus infectious disease: In ZIKV infection, we also observed an elevated IFN-γ-producing Th1 cell response, from 5.7% at baseline to 9.8% in ZIKV infection, and 14.1% in immune-modulated ZIKV infection, whereas Th2 or Th17 cell responses were not augmented (Supplementary Fig. 7).