Importantly, immune sera collected on 130 dpi from Bcl6 intact mice protected 6 of 9 (66.7%) AG6 mice from lethal ZIKV infection; in contrast, sera from Bcl6fl/flCd4-Cre mice or uninfected mice (PBS control) collected at the same time point failed to protect AG6 mice from weight loss (Fig. 4f), or death (Fig. 4g) after lethal infection. Here, BCL6 is linked to Zika virus infectious disease.