CR1 and malaria: Erythrocyte CR1 deficiency is common in some malaria-endemic countries such as Papua New Guinea (Cockburn et al., 2004) and India (Sinha et al., 2009), and is associated with protection against severe malaria in medium to high transmission areas (Cockburn et al., 2004; Sinha et al., 2009; Rout et al., 2011; Panda et al., 2012).