In patients with HR-positive breast cancer, the presence of baseline IGF-1R tumor expression was associated with a better DFS in univariate analyses (HR 0.433, 95% CI 0.198–0.946 P = 0.036), but not in multivariate analysis (HR 0.484, 95% CI 0.214–1.096, P = 0.082). This evidence concerns the gene IGF1R and breast cancer.