ACADM and cartilage disease: We also detected 20 overlapped genes in both MS and YBL (Table 1) in chondropathies, such as NSA2 (PTWAS MS = 2.47 × 10− 4, PTWAS YBL = 3.30 × 10− 4), RSRC1 (PTWAS MS = 4.54 × 10− 4, PTWAS YBL = 1.03 × 10− 4), NME6 (PTWAS MS = 9.93 × 10− 3, PTWAS YBL = 1.75 × 10− 3), NUDT2 (PTWAS MS = 1.85 × 10− 2, PTWAS YBL = 2.32 × 10− 2), and ACADM (PTWAS MS = 3.03 × 10− 2, PTWAS YBL = 4.14 × 10− 2).