Cyclin E (CCNE), which is required for the transition from G1 to S phase of the cell cycle via its interactions with cyclin dependent kinases (CDK), specifically CDK2, has been implicated in various carcinomas, including pituitary, breast, gastric, ovarian, lung, stomach, colorectal and bladder cancers [15–21]. The gene discussed is CCNE1; the disease is urinary bladder cancer.