Cyclin E (CCNE), which is required for the transition from G1 to S phase of the cell cycle via its interactions with cyclin dependent kinases (CDK), specifically CDK2, has been implicated in various carcinomas, including pituitary, breast, gastric, ovarian, lung, stomach, colorectal and bladder cancers [15–21]. Here, CCNE1 is linked to urinary bladder carcinoma.