CCND1 and bladder transitional cell carcinoma: We found that Yap1-knockdown does not change the mRNA expressions of CCND1 (Additional file 2: Figure S2B), CDK4/6 (Additional file 2: Figure S2C and D) and TEAD4 (Additional file 2: Figure S2E), only the expressions of CCNE1 and CCNE2 have been obviously decreased at transcriptional level (Additional file 2: Figure S2F and G), which further increases the possibility of that Yap1 is closely related to the regulation of both CCNE1 and CCNE2 in the BLCA cells.