After insulin administration, the blood glucose disappearance rate during the first 10 min (Kitt) markedly decreased (Fig. 2), and the area under the glycaemia curve significantly increased (~ 50%) in mice treated with pravastatin for 10 months (5496 ± 261 vs. 8150 ± 1086, n = 4–5, p < 0.05), characterizing an insulin resistance state induced by long-term treatment with pravastatin. Here, INS is linked to Insulin resistance.