Five patients died in 10 months (m), 13 m, 8 m, 24 m and 1 m, after the diagnosis of ovarian metastasis from lung adenocarcinoma, including a patient harboring an ALK rearrangement (LTO_1) who did not undergo targeted therapy and had hypothyroidism for 3 years. This evidence concerns the gene ALK and lung adenocarcinoma.