As Wnt/β-catenin pathway plays a crucial role in induction and maintenance of EMT, we detected the protein expression of the Wnt/β-catenin signaling genes for β-catenin, p-GSK3β, C-myc, and cyclin D1 in Caki-2 cells overexpressing CR-1 or in which CR-1 had been knocked down in 786-O and Caki-1 to explore the CR-1 mechanism underlying ccRCC metastasis. Here, MYC is linked to nonpapillary renal cell carcinoma.