Our study indicates that curcumin plays an anti-inflammatory role in MSU-induced inflammation by suppressing the degradation of IκBα, the NF-κB signaling pathway, the NLRP3 inflammasome activation, and the mitochondrial damage, strongly suggesting that curcumin may be used as a potential drug for the treatment of gout in the future. This evidence concerns the gene NFKB1 and gout.