In addition, TNF-α, IL-6, IL-8, NLR, PLR, IgE have been associated with LC risk in healthy subjects, being IL-6, lymphocytes, neutrophils, NLR, platelets, PLR, fibrinogen, A1AT, CRP and bilirubin poor prognostic factors in LC patients [11, 14, 30–32]. This evidence concerns the gene IGHE and laryngotracheoesophageal cleft.