CLEC10A and breast carcinoma: To substantiate our hypothesis that CLEC10A ligand expression is regulated by female sexual hormones, we studied the induction of glycan structures recognized by CLEC10A in the two estrogen and progesterone receptor (ER/PR) positive breast cancer cell lines T47D and MCF7 after withdrawal and re-addition of estrogen and progesterone, respectively (Fig. 2b).