We chose two inhibitors, WP1066 (a JAK2 inhibitor with diverse mechanisms of inhibition [39]), that we showed was active in primary cultures and in vivo, and Ruxolitinib (Ruxo), a high-affinity JAK1/2 inhibitor that blocks JAK activation and is currently used in the treatment of patients with high-risk myelofibrosis. The gene discussed is JAK1; the disease is myelofibrosis.