BDNF and epilepsy: In addition to the significant relationship to epilepsy identified by IPA (see Additional file 1: Table S1), the overlapping WP/RX2 gene set had a significant link to neuroinflammation despite the neuronal cultures being largely devoid of any glial cells, 41 genes of the BDNF-induced set of 56 neuroinflammation-linked genes were reversed by WP + B or RX2 + B treatment (73% of the gene set) (Fig. 4c).