BDNF and temporal lobe epilepsy: There is also a specific decrease (1.73 fold) in the expression of Gabra1 that is a member of the GABAR gene cluster which we have previously demonstrated to be regulated by BDNF using qRT-PCR in extracts of BDNF-treated primary neurons and hippocampal tissue extracted from the in vivo PILO model of temporal lobe epilepsy [23].