BDNF and epilepsy: While we discovered that co-treatment of neurons with BDNF (V + B) vs. RX1 + B produced similar transcriptomes, we found that a marked increase in the concentration of Ruxo (10 μM) plus BDNF (RX2 + B) attenuated the expression of multiple genes that were altered in response to BDNF, and most importantly, those that we previously identified in the PILO model of epilepsy.