IFNG and infection: Lower concentrations of IFN-γ may be related to the neutralizing anti–interferon-γ autoantibodies, which are increasingly being recognized as a cause of both adult-onset immunodeficiency and increased risk of infections with intracellular pathogens, including Cryptococcus neoformans, Histoplasma capsulatum, Talaromyces marneffei, and disseminated salmonellosis [21].