Histologically, BRAF mutant/MSS cancers show more adverse morphological features compared with BRAF/MSI cancers, such as frequent tumor budding; high-grade neuroendocrine carcinomatous component; a lack of tumor infiltrating lymphocytes; frequent lymphatic, perineural, and venous invasion; and increased lymph-node metastases [38,39,40]. This evidence concerns the gene BRAF and cancer.