As a danger signal, damage-associated molecular pattern molecules (DAMPs), such as high-mobility group box 1 (HMGB1) and adenosine triphosphate, are released from the cytoplasm of the irradiated tumor cells into the extracellular environment, allowing dendritic cells (DCs) to recognize dying cells and phagocytose them [51,99,100,101,102,103,104,105,106,107]. This evidence concerns the gene HMGB1 and neoplasm.