In particular, an Italian study has shown that, in young patients with a histological diagnosis of NAFLD, the presence of PNPLA3 GG polymorphism was associated with a higher prevalence of carotid plaques and intima-media thickening compared with the CC/CG genotype (53% vs. 32%, p  =  0.02; 62%vs.28%, p < 0.001, respectively), but also with intima-media thickening progression during follow-up [58]. The gene discussed is PNPLA3; the disease is metabolic dysfunction-associated steatotic liver disease.