PTK2 and central nervous system cancer: In glioma, L1CAM-ECD promotes cell migration and proliferation by a mechanism that depends on αvβ3 and αvβ5 integrins and FAK, and on FGFR1 activity [40,41,74,75], suggesting that the L1CAM-ECD mediates its effect by heterophilic interactions of both integrins and the FGFR1 in these tumors.