The HLA-B,C-specific mAb B1.23.2 reduces the motility of A375-M6 melanoma cells (Figure 4C); this effect is mediated by the interaction of HLA-B,C-specific antibodies with the corresponding antigens, since mAb B1.23.2 had no detectable effect on the motility of the FO-1 melanoma cells, which do not express HLA class I antigens (Figure 4D). This evidence concerns the gene HLA-B and melanoma.