ERVW-1 and infection: These data are consistent with the model that is depicted in Figure 4, which shows that extracellular Tat that is released by infected neighbour cells binds to trimeric Env on HIV, decreases the recognition of C-type lectin receptors, and promotes the engagement of RGD-binding integrins, which are expressed by antigen-presenting cells (APCs), such as inflammatory DCs, macrophages (Mo), and ECs that are present at the site of infection.