In this regard, our unpublished data indicate that infected lymphocytes that were treated with current antiretrovirals, while blocking productive infection and reducing the level of unspliced and singly-spliced RNA transcripts, continue to express RNA transcripts encoding for Tat, Rev, and Nef, which alters the expression ratio in favor of multispliced transcripts, consistent with reported results [88,89,90,91]. The gene discussed is S100B; the disease is infection.