Further, in a subsequent study in which the cynomolgus macaques were primed intramuscularly thrice with the biologically active HIV-1 Tat protein being delivered by anionic microspheres and boosted subcutaneously twice with Tat protein in Alum and then intravenously challenged with SHIV89.6P, control of infection correlated with both Tat-specific T-cell responses and Abs directed against the glutamine-rich (aa 61–75) and the RGD-integrin-binding (aa 71–85) regions of Tat [129]. The gene discussed is TAT; the disease is infection.