In its role as a multifunctional adaptor protein, syntenin has been implicated in a number of cellular events, such as receptor protein trafficking [7], developmental regulation of neuronal membrane architecture [8,9], synapse formation [10], axonal elongation [11], exosome production [12], and even the pathogenesis of various types of cancer cells, especially in invasion and stemness regulation [13,14]. Here, SDCBP is linked to cancer.